This study is an opportunity to analyse the consequences (for the citizen) of the setting up of space that is a genuine cross-border space as regards access to maternity care. It also underscores the importance of health cooperation in the Greater Region in order to avoid having areas of vulnerability. The examples studied in this regional space provide useful information for decision-makers in terms of territorial development. The analysis underscores the importance health cooperation based on collaboration at different levels: administrative, economic and technical, but also cultural in order to determine whether such an approach is feasible.