In spite of their small sizes, Luxembourg and Switzerland have a high demand for workers. In particular, they offer employment opportunities to people crossing the border to work. The situation in the main employment sites (Luxembourg, Basel, Geneva) – but also Ticino – is the object of the subject leaflet that 19 authors submit contributions with comparing perspectives. Under consideration of central context features and methodological considerations, the geographers, economists, sociologists and politologists considered in particular the labour market, cross-border everyday life and social perception of cross-border commuters. The multidisciplinary approach was eventually condensed by the editors into shared challenges between Luxembourg and Switzerland.